PEX6 (NP_000278, 881 a.a. ~ 980 a.a) partial recombinant protein with GST tag. The sequence is RVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPG SSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC
This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6.
Pathway
Peroxisome.
Citations
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