Anti-PEX12 (C-terminal) polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to amino acids at C-terminus of human PEX12. The sequence is RSHQACPITGYP

Conjugate

Application Notes

ELISA: 1:8000. & The optimal working dilution should be determined by the end user.

Alternative Names

PEX12; peroxisomal biogenesis factor 12; PAF-3; PBD3A; peroxisome assembly protein 12; peroxin 12; peroxin-12; peroxisome assembly factor 3;

Entrez Gene ID

UniProt ID

Antigen Description

This gene belongs to the peroxin-12 family. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS).

Pathway

Peroxisome;