Anti-PDGFD monoclonal antibody, clone FQS8377(3)

Antibody Isotype

IgG

Clone

FQS8377(3)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human SCDGFB aa 300 to the C-terminus. The exact sequence is proprietary.Database link: Q9GZP0

Conjugate

Application Notes

WB: 1/1000 - 1/2000; IHC-P: 1/100;

Alternative Names

PDGFD; platelet derived growth factor D; platelet-derived growth factor D; IEGF; MSTP036; SCDGF B; spinal cord derived growth factor B; PDGF-D; iris-expressed growth factor; spinal cord-derived growth factor B; spinal cord-derived growth factor-B; SCDGFB;

Entrez Gene ID

UniProt ID

Antigen Description

Potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. Activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet-derived growth factor receptor. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.

Pathway

Focal Adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; Gap junction, organism-specific biosystem; Gap junction, conserved biosystem; Melanoma, organism-specific biosystem; Melanoma, conserved biosystem.