Anti-PDE8B monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human PDE8B is used for rabbit immunization.

Conjugate

Alternative Names

PDE8B; phosphodiesterase 8B; high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B; hsPDE8B; cell proliferation-inducing gene 22 protein; 3,5 cyclic nucleotide phosphodiesterase 8B; ADSD; PPNAD3; FLJ11212;

Entrez Gene ID

UniProt ID

Antigen Description

Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the 5-prime,3-prime-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies. The PDE8 family contains high-affinity cAMP-specific, IBMX (3-isobutyl-1-methyl-xanthine)-insensitive PDEs, such as PDE8B. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that presumably accounts for the distinctive regulatory properties unique to the individual families.

Pathway

G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Morphine addiction, organism-specific biosystem; Morphine addiction, conserved biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem;