Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Mali, RS; Peng, GH; et al. FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. BMC MOLECULAR BIOLOGY 9:-(2008).
Arroba, AI; Alvarez-Lindo, N; et al. Microglia-Mediated IGF-I Neuroprotection in the rd10 Mouse Model of Retinitis Pigmentosa. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 52:9124-9130(2011).
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