Anti-PDE3A (aa 533-640) polyclonal antibody

Species Reactivity

Human

Immunogen

PDE3A (NP_000912, 533 a.a. ~ 640 a.a) partial recombinant protein with GST tag. The sequence is TPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPY SQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNE

Conjugate

Alternative Names

PDE3A; phosphodiesterase 3A, cGMP-inhibited; CGI-PDE; CGI-PDE A; CGI-PDE-A; cGMP-inhibited 3,5-cyclic phosphodiesterase A; cyclic GMP-inhibited phosphodiesterase A; cAMP phosphodiesterase, myocardial cGMP-inhibited;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Pathway

G alpha (s) signalling events; Hemostasis; Insulin signaling pathway; Morphine addiction