General Notes
This product (Catalog No. DPABH-27305) is a rabbit-derived polyclonal antibody raised against human PDE2A, targeting the amino acid region 241–387 of the protein. It has been affinity purified by Protein A. Phosphodiesterase 2A (PDE2A) is a dual-substrate enzyme encoded by the PDE2A gene on chromosome 11q13.4, which catalyzes the hydrolysis of both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) to their respective 5'-monophosphates, thereby modulating intracellular levels of these key second messengers in signal transduction pathways. The enzyme's activity is uniquely stimulated by cGMP binding, which allosterically enhances the degradation of both substrates, allowing PDE2A to integrate and fine-tune parallel cAMP and cGMP signaling cascades.
DPABH-27305 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-27305 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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