Recombinant fragment, corresponding to N terminal amino acids of Human Mel18 with a 26 kDa proprietary tag. (Uniprot: P35227).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/1000 - 1/3000;
Target
Alternative Names
PCGF2; polycomb group ring finger 2; MEL-18; RNF110; ZNF144; polycomb group RING finger protein 2; ring finger protein 110; zinc finger protein 144; DNA-binding protein Mel-18;
Transcriptional repressor. Binds specifically to the DNA sequence 5-GACTNGACT-3. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.
Citations
Publication ()
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COA
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