Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human PCGF1 aa 150-250. The exact sequence is proprietary.Database link: Q9BSM1
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/10000 - 1/50000; Flow Cyt: 1/100;
Target
Alternative Names
PCGF1; polycomb group ring finger 1; polycomb group RING finger protein 1; MGC10882; NSPC1; RNF68; RING finger protein 68; nervous system Polycomb-1; RNF3A-2; 2010002K04Rik; FLJ43754;
PCGF1 is a component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. It represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). PCGF1 als promotes cell cycle progression and also enhances cell proliferation, thus it may have a positive role in tumor cell growth.
Citations
Publication ()
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