Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human PCBP2/hnRNP E2 aa 150-250. The exact sequence is proprietary.Database link: Q15366
Applications
Application Notes
Flow Cyt: 1/110; IP: 1/40 - 1/60; ICC/IF: 1/250; WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100.
Target
Alternative Names
PCBP2; poly(rC) binding protein 2; poly(rC)-binding protein 2; heterogenous nuclear ribonucleoprotein E2; hnRNP E2; HNRPE2; alpha-CP2; heterogeneous nuclear ribonucleoprotein E2; hnRNP-E2; MGC110998;
Product Background
Antigen Description
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.
Pathway
Gene Expression, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem; mRNA Splicing, organism-specific biosystem;
Citations
Publication ()
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COA
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