Anti-PCBD1 (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

PCBD1 (AAH06324, 1 a.a. ~ 104 a.a) full-length recombinant protein with GST tag. The sequence is MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKL DHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT

Conjugate

Alternative Names

PCBD1; pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; PCD; PHS; DCOH; PCBD; pterin-4-alpha-carbinolamine dehydratase; dimerizing cofactor for HNF1; 4-alpha-hydroxy-tetrahydropterin dehydratase; phenyla

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants.

Pathway

Metabolism; Phenylalanine and tyrosine catabolism;