Anti-PBX1 (aa 213-321) polyclonal antibody

Species Reactivity

Human

Immunogen

PBX1 (NP_002576, 213 a.a. ~ 321 a.a) partial recombinant protein with GST tag. The sequence is MQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKK CGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGS

Conjugate

Alternative Names

PBX1; pre-B-cell leukemia homeobox 1; pre-B-cell leukemia transcription factor 1; homeobox protein PRL; homeobox protein PBX1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Pathway

Developmental Biology; SIDS Susceptibility Pathways; Transcriptional regulation of pluripotent stem cells;