Specifications
Immunogen
Recombinant fragment corresponding to amino acids 299-588 of Human PADI4 (NP_036519) produced in E.coli.
Applications
Application Notes
WB: 1/2000; IHC-P: 1/150; ICC/IF: 1/100;
Target
Alternative Names
PADI4; peptidyl arginine deiminase, type IV; PADI5, peptidyl arginine deiminase, type V; protein-arginine deiminase type-4; PAD; PDI4; PDI5; HL-60 PAD; PADI-H protein; protein-arginine deiminase type IV; peptidyl arginine deiminase, type V; PAD4; PADI5;
Product Background
Antigen Description
Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at Arg-8 and/or Arg-17 and histone H4 at Arg-3, which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at Arg-2142, which favors its interaction with NCOA2/GRIP1.
Pathway
protein citrullination, organism-specific biosystem; protein citrullination, conserved biosystem;
Citations
Publication ()
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COA
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