Anti-P4HB polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human; Monkey

Immunogen

Synthetic peptide conjugated to KLH, derived from the sequence around Proline 329 of Human P4HB

Conjugate

Application Notes

WB: 1/1000; IHC-P: 1/50; ICC/IF: 1/50.

Alternative Names

P4HB; prolyl 4-hydroxylase, beta polypeptide; ERBA2L, PO4DB, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide; procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide (protein

Entrez Gene ID

UniProt ID

Antigen Description

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.

Pathway

Chylomicron-mediated lipid transport; Lipid digestion, mobilization, and transport; Lipoprotein metabolism; Metabolism; Metabolism of lipids and lipoproteins; Protein processing in endoplasmic reticulum;