The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants.
Pathway
Class A/1 (Rhodopsin-like receptors); G alpha (q) signalling events; GPCR downstream signaling; GPCR ligand binding; GPCRs, Class A Rhodopsin-like; Gastrin-CREB signalling pathway via PKC and MAPK; Neuroactive ligand-receptor interaction; Nucleotide GPCRs; Nucleotide-like (purinergic) receptors; P2Y receptors; PI3K-Akt signaling pathway.
Citations
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