Anti-P2RX1 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human P2RX1 is used for rabbit immunization.

Conjugate

Alternative Names

P2RX1; purinergic receptor P2X, ligand-gated ion channel, 1; P2X purinoceptor 1; P2X1; ATP receptor; P2X1 receptor; P2X receptor, subunit 1;

Entrez Gene ID

UniProt ID

Antigen Description

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.

Pathway

Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Elevation of cytosolic Ca2+ levels, organism-specific biosystem; Hemostasis, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem; Platelet calcium homeostasis, organism-specific biosystem;