General Notes
This product (Catalog No. DPABH-01115) is a rabbit-derived polyclonal antibody raised against human OR9G4. It has been affinity purified by Protein A. OR9G4 is a protein-coding gene in humans that encodes olfactory receptor 9G4, a G protein-coupled receptor (GPCR) belonging to the largest multigene family in the genome, which is responsible for detecting odorant molecules in the nasal epithelium to initiate neuronal signaling and the perception of smell. The gene is located on the long arm of chromosome 11 at position 11q12.1 and consists of two exons, with a single coding exon typical of olfactory receptor genes. It produces two validated mRNA isoforms (NM_001005284.2 and NM_001390832.1), both encoding the same 312-amino-acid protein isoform (NP_001005284.2 or NP_001377761.1) featuring a conserved 7-transmembrane domain characteristic of class A GPCRs. OR9G4 functions by recognizing specific odorants, coupling to G proteins (likely Golf in olfactory neurons), and triggering intracellular signaling cascades that lead to action potentials in olfactory sensory neurons. As part of the olfactory signaling pathway, OR9G4 contributes to the human sense of smell, though individual olfactory receptors like this one typically respond to a narrow range of odorants, with broader odor discrimination arising from combinatorial activation across the ~400 functional OR genes. The gene has orthologs in other mammals, such as the mouse Or9g4 (also known as Olfr1006), indicating evolutionary conservation of its role in olfaction. While primarily expressed in olfactory tissues, olfactory receptors have been detected in ectopic contexts and implicated in potential non-olfactory functions, though such roles remain under investigation.
DPABH-01115 is suitable for use in WB 1 (500-1:1000), IF/ICC 1 (100-1:500) applications.
DPABH-01115 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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