General Notes
This product (Catalog No. DPABH-24328) is a rabbit-derived polyclonal antibody raised against human OR8J1. It has been affinity purified by Protein A. OR8J1 is a protein-coding gene located on the long arm of human chromosome 11 at position 11q12.1, encoding the olfactory receptor protein known as OR8J1 or OR11-183. This receptor belongs to the G protein-coupled receptor 1 family and functions as an odorant receptor, interacting with odorant molecules in the nasal epithelium to initiate a neuronal response that triggers the perception of smell. The OR8J1 gene spans approximately 7.2 kilobases and consists of a single exon, producing a transcript that translates into a 316-amino-acid protein with seven transmembrane domains characteristic of olfactory receptors. Expression of OR8J1 is primarily restricted to the olfactory epithelium in the nose, where it contributes to the vast repertoire of over 400 human olfactory receptors responsible for discriminating thousands of distinct odors. OR8J1 exemplifies the evolutionary dynamics of the olfactory gene cluster, with orthologs identified in other mammals such as mice and chimpanzees. While OR8J1 has been implicated in bioinformatics associations with neurodevelopmental conditions like syndromic X-linked intellectual disability, it lacks established causal links to human diseases in major databases such as OMIM. Research on OR8J1 primarily focuses on its role in olfaction, with potential applications in understanding anosmia and sensory perception disorders, though specific ligands or deorphanization studies remain limited. The gene's nomenclature is approved by the HUGO Gene Nomenclature Committee, reflecting its classification within the olfactory receptor family 8 subfamily J.
DPABH-24328 is suitable for use in WB 1 (500-1:1000), IF/ICC 1 (100-1:500) applications.
DPABH-24328 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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