General Notes
This product (Catalog No. DPABH-00991) is a rabbit-derived polyclonal antibody raised against human OR7A10. It has been affinity purified by Protein A. OR7A10 is a protein-coding gene in Homo sapiens that encodes the olfactory receptor 7A10 (OR7AA), a member of the G protein-coupled receptor 1 family responsible for detecting odorant molecules in the nasal epithelium to initiate the perception of smell. Located on the reverse strand of chromosome 19 at position 19p13.12 (GRCh38: 14,840,466-14,848,922), it consists of two exons and produces a 309-amino-acid protein with seven transmembrane domains typical of olfactory receptors. As part of the largest gene family in the human genome, comprising over 800 olfactory receptor genes, OR7A10 contributes to the diverse repertoire of scent detection, with its expression primarily confined to olfactory sensory neurons in the nose. The gene's protein product mediates G protein activation upon odorant binding, triggering intracellular signaling cascades that transmit olfactory signals to the brain. While no specific diseases are directly associated with OR7A10 variants in major databases, rare coding variations in the gene have been implicated in modulating cognitive performance in some exome-wide studies, though further research is needed to confirm such links. OR7A10, also known by aliases such as OR19-18 and OST027, was identified through efforts to map the human olfactory receptor repertoire and is annotated in resources like the HUGO Gene Nomenclature Committee (HGNC:8356). It has 213 orthologs across vertebrates and 130 paralogs within the human genome, underscoring its evolutionary conservation in olfaction. The gene's sequence is part of the Consensus Coding Sequence (CCDS) project (CCDS32936.1), ensuring standardized annotation for research.
DPABH-00991 is suitable for use in WB 1 (500-1:1000), IF/ICC 1 (100-1:500) applications.
DPABH-00991 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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