General Notes
This product (Catalog No. DPABH-01135) is a rabbit-derived polyclonal antibody raised against human OR51G2. It has been affinity purified by Protein A. OR51G2 is a protein-coding gene in humans that encodes olfactory receptor 51G2, a member of the G protein-coupled receptor 1 family specialized in odor detection. This receptor protein, consisting of 314 amino acids with a molecular mass of approximately 35 kDa, features a characteristic seven-transmembrane domain structure typical of olfactory receptors. Located on the short arm of chromosome 11 at cytogenetic band 11p15.4 (genomic coordinates: chr11:4,912,588-4,919,350 reverse strand on GRCh38), the gene spans about 6.8 kb and contains a single coding exon. As an odorant receptor, OR51G2 interacts with specific odorant molecules in the nasal epithelium to trigger a neuronal response via G protein-mediated signal transduction, contributing to the sensory perception of smell. It enables olfactory receptor activity and is involved in pathways such as olfactory signaling, detection of chemical stimuli, and G protein-coupled receptor signaling. Expression of OR51G2 is primarily observed in olfactory receptor neurons within the nose, though it has also been detected in male germ line stem cells of the testis. The gene belongs to a large superfamily of over 800 olfactory receptor genes in humans, representing the largest gene family in the genome, with many members undergoing evolutionary selection for sensory adaptation. Notable aspects include its paralog OR51G1, which shares structural similarities, and orthologs in other mammals such as mouse Olfr577 (85% sequence similarity). Genetic variants in OR51G2, including missense mutations, are documented in databases like ClinVar, though most are of uncertain clinical significance; one large deletion encompassing the locus has been associated with thalassemia due to effects on nearby beta-globin regulation. Genome-wide association studies have linked single nucleotide polymorphisms near OR51G2, such as rs2595975, to traits like gut microbiome composition and breastfeeding duration. Overall, OR51G2 exemplifies the diversity and evolutionary dynamics of the human olfactory repertoire, with implications for sensory biology and potential disease contexts.
DPABH-01135 is suitable for use in WB 1 (500-1:1000), IF/ICC 1 (100-1:500) applications.
DPABH-01135 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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