General Notes
This product (Catalog No. DPABH-01155) is a rabbit-derived polyclonal antibody raised against human OR51D1. It has been affinity purified by Protein A. OR51D1 is a protein-coding gene in humans that encodes the olfactory receptor protein known as olfactory receptor 51D1, a member of the G protein-coupled receptor 1 (GPCR1) family with a characteristic seven-transmembrane domain structure. This receptor is primarily involved in the detection of odorant molecules within the nasal epithelium, initiating a neuronal signaling cascade that contributes to the perception of smell through activation of G proteins and subsequent olfactory transduction pathways. Located on the short arm of chromosome 11 at cytogenetic band 11p15.4 (genomic coordinates: chr11:4,637,477-4,643,060 on GRCh38), the gene spans approximately 5.6 kb and produces a 324-amino-acid protein with a molecular mass of 35,839 Da. Aliases for OR51D1 include OR51D1Q and OR11-14, reflecting its classification within the large superfamily of olfactory receptors, which comprises over 300 functional genes in humans clustered across multiple chromosomes. Functionally, OR51D1 exhibits G protein-coupled receptor activity, olfactory receptor activity, and signaling receptor activity, as annotated in Gene Ontology terms, enabling it to bind odorants and transduce chemical stimuli into electrical signals for sensory perception. It participates in key biological processes such as G protein-coupled receptor signaling, sensory perception of smell, and detection of chemical stimuli involved in smell perception, primarily within the olfactory signaling pathway. Expression of OR51D1 is noted in specific tissues including stromal cells of the endometrium and prostate gland, though broader tissue distribution data is limited. Genome-wide association studies (GWAS) have linked genetic variants in or near OR51D1 to traits such as smoking initiation (association score 9.7), body height (9.0), and measures of smoking behavior and status, suggesting potential roles beyond olfaction in behavioral or physiological phenotypes. However, no direct associations with monogenic diseases have been established, and functional studies remain sparse, with the gene showing moderate variation intolerance (RVIS percentile: 86.4%). As part of the olfactory receptor repertoire, OR51D1 exemplifies the evolutionary conservation of chemosensory mechanisms, with orthologs identified in other mammals like mice (Or51d1) and rats.[.
DPABH-01155 is suitable for use in WB 1 (500-1:1000), IF/ICC 1 (100-1:500) applications.
DPABH-01155 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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