General Notes
This product (Catalog No. DPABH-21682) is a rabbit-derived polyclonal antibody raised against human OR4Q3. This antibody exhibits cross-reactivity with OR4Q3 from rat. It has been affinity purified by Protein A. OR4Q3 is a protein-coding gene in humans that encodes olfactory receptor 4Q3, a G protein-coupled receptor (GPCR) belonging to the olfactory receptor family, which plays a crucial role in odor detection by interacting with odorant molecules in the nasal epithelium to initiate neuronal signaling for smell perception. Located on the forward strand of chromosome 14 at position 14q11.2 (GRCh38: 19,743,571-19,749,469), OR4Q3 spans approximately 5.9 kb and consists of a single coding exon typical of this gene family. As part of the largest multigene family in the human genome—comprising over 900 olfactory receptor genes—OR4Q3 contributes to the diversity of olfactory signaling through its seven-transmembrane domain structure, which facilitates ligand binding and G protein-mediated transduction of odorant signals. The encoded protein exists in two validated isoforms, the primary one with 312 amino acids, and is expressed primarily in olfactory sensory neurons, though expression data from fetal tissues indicate broader potential roles. Officially approved by the HUGO Gene Nomenclature Committee with the symbol OR4Q3 (HGNC:15426), it was previously known by aliases such as C14orf13 and OR14-3, reflecting its evolutionary conservation across vertebrates with 71 orthologs identified. While no specific diseases are directly associated with OR4Q3 variants in current records, olfactory receptors like this one are studied for their involvement in chemosensory evolution and potential links to sensory disorders.
DPABH-21682 is suitable for use in WB 1 (1000-3000), IF/ICC 1 (100-1:500) applications.
DPABH-21682 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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