General Notes
This product (Catalog No. DPABH-13303) is a rabbit-derived polyclonal antibody raised against human OR4N2. This antibody exhibits cross-reactivity with OR4N2 from mouse. It has been affinity purified by Protein A. OR4N2 is a protein-coding gene in humans that encodes olfactory receptor 4N2, a seven-transmembrane G protein-coupled receptor (GPCR) specialized for detecting odorant molecules in the nasal olfactory epithelium to trigger neuronal signaling and the perception of smell. This receptor belongs to the largest multigene family in the human genome, consisting of over 800 olfactory receptor genes clustered across multiple chromosomes, which collectively enable the recognition of diverse chemical stimuli. The OR4N2 gene is located on the forward strand of chromosome 14 at cytogenetic band 14q11.2, spanning approximately 111 kilobases with two exons in the GRCh38 reference assembly (coordinates 19,719,015–19,830,253). Functionally, OR4N2 mediates the initial step in olfaction by binding specific odorants, activating heterotrimeric G proteins (primarily Golf in olfactory neurons), and initiating intracellular cascades that lead to action potentials in sensory neurons. Gene Ontology annotations confirm its roles in G protein-coupled receptor activity, olfactory receptor activity, signal transduction, and sensory perception of smell, including the detection of chemical stimuli. The encoded protein features conserved domains typical of rhodopsin-like GPCRs, such as the 7tm_1 domain (residues 41–287) and 7tm_4 olfactory receptor domain (residues 35–302), which facilitate ligand binding and transmembrane signaling.
DPABH-13303 is suitable for use in IF/ICC 1 (100-1:500), WB 1 (1000-3000), IHC 1 (50-1:200) applications.
DPABH-13303 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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