General Notes
This product (Catalog No. DPABH-08944) is a rabbit-derived polyclonal antibody raised against human OR2AK2. It has been affinity purified by Protein A. OR2AK2 is a protein-coding gene located on the long arm of human chromosome 1 (1q44) that encodes the olfactory receptor family 2 subfamily AK member 2 protein, a G protein-coupled receptor (GPCR) specialized for detecting odorant molecules in the nasal cavity to trigger the sensory perception of smell. The gene spans approximately 1.15 kilobases and produces a 335-amino-acid protein with seven transmembrane domains, characteristic of the rhodopsin-like GPCR superfamily. As part of the largest gene family in the human genome, consisting of over 300 intact olfactory receptor genes, OR2AK2 contributes to the diversity of odor detection by recognizing specific structurally related odorants within its subfamily. The OR2AK2 protein is primarily expressed in olfactory receptor neurons within the olfactory epithelium of the nose, where it plays a key role in the initial steps of the olfactory signaling pathway, including G protein activation and downstream signal transduction leading to neuronal depolarization. Expression data also indicate ectopic presence in non-olfactory tissues, such as the testis (at levels up to 8-fold higher than average), brain regions like the nucleus accumbens and spinal cord, and male germ line stem cells, suggesting potential additional functions beyond olfaction, though these remain underexplored. Evolutionarily conserved across mammals, with orthologs in species like chimpanzees (99% similarity), cows, and dogs, OR2AK2 exemplifies the genomic clustering of olfactory receptors, aiding in their coordinated regulation and functional specialization. Notable associations link variants in OR2AK2 to hematological traits, such as reticulocyte count and platelet distribution width, through genome-wide association studies (GWAS), highlighting possible pleiotropic effects. Additionally, text-mining evidence connects the gene to Immunodeficiency 40 (IMD40), a combined immunodeficiency disorder, though direct causal roles require further validation; the gene exhibits high intolerance to variation (86.2% residual variation intolerance score), implying sensitivity to mutations that could impact neurodevelopment or immune function. Ongoing research into olfactory receptor ectopic expression underscores OR2AK2's potential involvement in processes like cerebral cortical development and even cancer cell lines across tissues, where it shows elevated expression, but primary olfactory roles dominate current understanding.
DPABH-08944 is suitable for use in IF/ICC 1 (100-1:500) application.
DPABH-08944 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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