General Notes
This product (Catalog No. DPABH-24178) is a rabbit-derived polyclonal antibody raised against human OR2AJ1. It has been affinity purified by Protein A. OR2AJ1 is a protein-coding gene in humans that encodes the olfactory receptor family 2 subfamily AJ member 1 (OR2AJ1), a G protein-coupled receptor (GPCR) involved in olfaction. Located on chromosome 1q44, the gene spans approximately 10.5 kb with two exons and produces a 328-amino-acid protein featuring the characteristic 7-transmembrane domain structure of olfactory receptors. Also known by aliases such as OR2AJ1P and OR2AJ1Q, it is part of the largest gene family in the human genome, comprising over 800 olfactory receptor genes that arose from single coding-exon structures in most cases. The OR2AJ1 protein functions by interacting with odorant molecules in the nasal epithelium to initiate a neuronal response, triggering the perception of smell through G protein-mediated signal transduction. Expressed primarily in olfactory sensory neurons, it shares structural similarities with other GPCRs involved in neurotransmitter and hormone signaling, enabling the detection and discrimination of diverse scents. While specific ligands for OR2AJ1 remain under investigation, its role aligns with the broader olfactory signaling pathway, where activation leads to cyclic AMP production and depolarization of sensory neurons. Genetic variations in OR2AJ1, documented in databases like ClinVar and dbSNP, may influence individual olfactory sensitivity, though no direct associations with diseases have been firmly established to date.
DPABH-24178 is suitable for use in WB 1 (500-1:1000), IF/ICC 1 (100-1:500) applications.
DPABH-24178 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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