General Notes
This product (Catalog No. DPABH-10979) is a rabbit-derived polyclonal antibody raised against human OR1C1. It has been affinity purified by Protein A. OR1C1 (olfactory receptor family 1 subfamily C member 1) is a protein-coding gene in humans that encodes an olfactory receptor protein, a member of the large G protein-coupled receptor (GPCR) superfamily responsible for detecting odorant molecules in the nasal epithelium to initiate the perception of smell. This receptor, designated OR1C1, features a characteristic seven-transmembrane domain structure typical of rhodopsin-like GPCRs and belongs to the class A/1 subfamily of olfactory receptors, which constitute the largest gene family in the human genome with over 400 functional members. The gene is located on the long arm of chromosome 1 at position 1q44 (GRCh38 coordinates: 247754846-247760556, complement strand) and consists of two exons, with the coding sequence distributed across both, producing a 314-amino-acid protein (UniProt accession: Q15619) that is primarily expressed in olfactory sensory neurons within the nose. Upon binding odorants, OR1C1 activates G protein-mediated signaling pathways, leading to neuronal depolarization and transmission of olfactory signals to the brain via the olfactory nerve. While its primary role is in olfaction, OR1C1 expression has also been detected in male germ cells across several mammalian species, suggesting potential non-olfactory functions in reproduction, though these remain underexplored. The gene has aliases including OR1-42 and TPCR27, and it is conserved in structure among vertebrates, underscoring its evolutionary importance in chemosensory detection. Rare variants in OR1C1 have been identified in individuals with autism spectrum disorder.
DPABH-10979 is suitable for use in WB 1 (1000-3000) application.
DPABH-10979 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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