Anti-OPHN1 (aa 641-734) polyclonal antibody

Species Reactivity

Human

Immunogen

OPHN1 (NP_002538, 641 a.a. ~ 734 a.a) partial recombinant protein with GST tag. The sequence is QRSGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTK TPSFHIKRPAPRPLAHHKEGDADSFSKVRPPGEK

Conjugate

Alternative Names

OPHN1; oligophrenin 1; OPN1; MRX60; ARHGAP41; oligophrenin-1; mental retardation, X-linked 60; oligophrenin-1, Rho-GTPase activating protein;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism.

Pathway

Regulation of RhoA activity; Signal Transduction;