Synthetic peptide corresponding to a region within internal sequence amino acids 416-465 (ITISQQLGLE LSTVSNFFMN ARRRSLDKWQ DEGSSNSGNS SSSSSTCTKA) of human HNF6 (NP_0044890).
HNF6, also known as ONECUT1, is a member of the homeodomain transcription factor family. HNF6 functions as a transcriptional activator that controls the development of pancreatic ducts during development. HNF6 binds to gene promoters such as those of HNF3B and TTR and is important for the transcription of genes regulating liver development.
Pathway
Developmental Biology; Maturity onset diabetes of the young; Regulation of beta-cell development; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
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