Rabbit Anti-Human OGT (N-terminal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

A synthesized peptide derived from human OGT, corresponding to a region within N-terminal amino acids.

Conjugate

Application Notes

WB 1:500-1:2000
IHC 1:50-1:200

General Notes

This product (Catalog No. DPABH-16249) is a rabbit-derived polyclonal antibody raised against human OGT. This antibody exhibits cross-reactivity with OGT from mouse and rat. It has been affinity purified by Protein A. O-linked N-acetylglucosamine transferase (OGT) catalyzes the attachment of N-acetylglucosamine (GlcNAc) monosaccharides to the hydroxyl group of serine or threonine residues of numerous nuclear and cytoplasmic proteins and may play important roles in a large number of diverse intracellular processes ranging from translational control, transcription, transcriptional repression, INS resistance and regulation of the cell cycle. It exists as a heterotrimeric complex with two 110 kDa and one 70 kDa subunits. Recent studies have shown that O-GlcNAcylation plays essential roles in cancer formation and progression. O-GlcNAcylation as well as OGT expression was found to be significantly elevated in the cancer tissues.
DPABH-16249 is suitable for use in WB 1 (500-1:2000), IHC 1 (50-1:200) applications.
DPABH-16249 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Entrez Gene ID

UniProt ID