Synthetic peptide corresponding to a region within N-terminal amino acids 2-51 (AQSTMPHKCD DVLSQDELRK KLYQTFKDRG ILDTLKTQLR NQLVHELMHP) of Rat OFD1 (NP_001100431).
Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis.
Pathway
Cell Cycle; Cell Cycle, Mitotic; Centrosome maturation; G2/M Transition; Loss of Nlp from mitotic centrosomes; Loss of proteins required for interphase microtubule organization??from the centrosome; Mitotic G2-G2/M phases
Citations
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