Anti-OCRL monoclonal antibody, clone 5B7

Antibody Isotype

IgG2a

Clone

5B7

Species Reactivity

Human

Immunogen

Recombinant fragment: SGLLGFEDNF SSMNLDKKIN SQNQPTGIHR EPPPPPFSVN KMLPREKEAS NKEQPKVTNT MRKLFVPNTQ SGQREGLIKH ILAKREKEYV NIQTF, corresponding to amino acids 146-240 of Human INPP5F (NP_000267) with a 26 kDa proprietary tag.

Conjugate

Application Notes

WB: 1/500 - 1/1000; IHC-P: 5 μg/ml;

Alternative Names

OCRL; oculocerebrorenal syndrome of Lowe; inositol polyphosphate 5-phosphatase OCRL-1; OCRL1; Lowe oculocerebrorenal syndrome protein; phosphatidylinositol polyphosphate 5-phosphatase; LOCR; NPHL2; INPP5F; OCRL-1;

Entrez Gene ID

UniProt ID

Antigen Description

Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes.

Pathway

1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), organism-specific biosystem; 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), conserved biosystem; 3-phosphoinositide degradation, organism-specific biosystem; 3-phosphoinositide degradation, conserved biosystem; Clathrin derived vesicle budding, organism-specific biosystem; D-myo-inositol (1,3,4)-trisphosphate biosynthesis, organism-specific biosystem; D-myo-inositol (1,3,4)-trisphosphate biosynthesis, conserved biosystem.