Anti-Norketamine monoclonal antibody (DMAB27408)
Sheep anti-Norketamine monoclonal antibody for ELISA, WB, Dot, IHC, IA
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Norketamine antibody; Sheep Anti-Norketamine Monoclonal Antibody; Anti-Norketamine Monoclonal Antibody; Norketamine Monoclonal Antibody; Sheep Anti-Norketamine MAb; Anti-Norketamine MAb
Ketamine is absorbable via intravenous, intramuscular, oral, and topical routes due to both its water and lipid solubility.  When administered orally, Ketamine undergoes first-pass metabolism, where it is biotransformed in the liver by CYP3A4 (major), CYP2B6 (minor), and CYP2C9 (minor) iso-enzymes into norketamine (through N-demethylation) and finally dehydronorketamine.  Intermediate in the biotransformation of norketamine into dehydronorketamine is the hydroxylation of norketamine into 5-hydroxynorketamine by CYP2B6 and CYP2A6. Dehydronorketamine, followed by norketamine, is the most prevalent metabolite detected in urine.
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Mossner, LD; Schmitz, A; et al. Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans. AMERICAN JOURNAL OF VETERINARY RESEARCH 72:1505-1513(2011).
Yang, TT; Zhao, CC; et al. Synthesis and Identification of Hapten and Complete Antigen of Norketa mine. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 38:109-112(2010).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.