Anti-Norketamine monoclonal antibody (DMAB27408)
Sheep anti-Norketamine monoclonal antibody for ELISA, WB, Dot, IHC, IA
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Norketamine antibody; Sheep Anti-Norketamine Monoclonal Antibody; Anti-Norketamine Monoclonal Antibody; Norketamine Monoclonal Antibody; Sheep Anti-Norketamine MAb; Anti-Norketamine MAb
Ketamine is absorbable via intravenous, intramuscular, oral, and topical routes due to both its water and lipid solubility.  When administered orally, Ketamine undergoes first-pass metabolism, where it is biotransformed in the liver by CYP3A4 (major), CYP2B6 (minor), and CYP2C9 (minor) iso-enzymes into norketamine (through N-demethylation) and finally dehydronorketamine.  Intermediate in the biotransformation of norketamine into dehydronorketamine is the hydroxylation of norketamine into 5-hydroxynorketamine by CYP2B6 and CYP2A6. Dehydronorketamine, followed by norketamine, is the most prevalent metabolite detected in urine.
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Yanagihara, Y; Kariya, S; et al. Involvement of CYP2B6 in N-demethylation of ketamine in human liver microsomes. DRUG METABOLISM AND DISPOSITION 29:887-890(2001).
Zhang, WD; Su, P; et al. DEVELOPMENT OF A SENSITIVE BIOTIN-AVIDIN AMPLIFIED ENZYME-LINKED IMMUNOSORBENT ASSAY FOR THE DETERMINATION OF KETAMINE IN BIOLOGICAL SAMPLES. JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY 31:205-216(2010).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.