Anti-NUDT6 monoclonal antibody (DCABH-611)

Mouse anti-Human NUDT6 monoclonal antibody for WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
3F4
Species Reactivity
Human
Immunogen
Recombinant full length protein of Human NUDT6 (NP_009014), produced in HEK293T cell.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/200 - 1/500;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
NUDT6; nudix (nucleoside diphosphate linked moiety X)-type motif 6; nucleoside diphosphate-linked moiety X motif 6; FGF AS; FGF2AS; gfg
Entrez Gene ID
UniProt ID

Product Background


Gene summary
NUDT6 (Nudix Hydrolase 6) is a Protein Coding gene. Diseases associated with NUDT6 include pulmonary capillary hemangiomatosis and gingival overgrowth. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. GO annotations related to this gene include hydrolase activity and growth factor activity. This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Antigen Description
May contribute to the regulation of cell proliferation. Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene. 0The function about NUDT6 antigen include growth factor activity; hydrolase activity.

Citations


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References


Taniguchi, M; Hayashi, T; et al. Fine mapping of quantitative trait loci for meat color on Sus scrofa chromosome 6: Analysis of the swine NUDT7 gene. JOURNAL OF ANIMAL SCIENCE 88:23-31(2010).
Sun, L; Yu, SB; et al. NUDT6, the FGF-2's antisense gene, showed associations with fat deposition related traits in pigs. MOLECULAR BIOLOGY REPORTS 39:4119-4126(2012).

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