General Notes
This product (Catalog No. DPABH-21675) is a rabbit-derived polyclonal antibody raised against human NTN3, targeting the amino acid region 28–207 of the protein. This antibody exhibits cross-reactivity with Human NTN3 from mouse and rat. It has been affinity purified by Protein A. NTN3 (Netrin-3), also known as NTN2L. NTN3 (Netrin-3) is predicted to be located in the Golgi apparatus and extracellular region, and it is also predicted to be active in the basement membrane. It is detected in various amounts in the skin, esophagus, bronchus, nasal cavity, kidney, and vagina in healthy human tissues (PMID: 37345154). The protein is predicted to enable signaling receptor binding activity and is involved in animal organ morphogenesis, neuron projection development, and tissue development. Netrins, including NTN3, are a group of proteins that exhibit structural homology to the extracellular matrix protein laminin and influence neurological and tumor progression. NTN3, along with other netrin family members, may play a role in tumor growth and migration in specific organs where they are expressed, potentially affecting disease progression. However, further research is needed to elucidate the precise prognostic and biological implications of NTN3 in various diseases, including cancer (PMID: 32251318). The molecular weight of NTN3 is 62 kDa. It is possible that the protein has glycosylation modification.
DPABH-21675 is suitable for use in Western blot (WB) (1:500–1:2,000) application.
DPABH-21675 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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