NSMAF (NP_003571, 818 a.a. ~ 917 a.a) partial recombinant protein with GST tag. The sequence is RHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVLSGSQSGELLVWDLLGAK ISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQY
Conjugate
Unconjugated
Target
Alternative Names
NSMAF; neutral sphingomyelinase (N-SMase) activation associated factor; FAN; protein FAN; factor associated with N-SMase activation; factor associated with neutral sphingomyelinase activation;
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Pathway
TNF receptor signaling pathway.
Citations
Publication ()
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