Anti-NR5A2 monoclonal antibody, clone FQS8111

Antibody Isotype

IgG

Clone

FQS8111

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide corresponding to residues in Human NR5A2/ LRH1.

Conjugate

Application Notes

WB: 1/1000 - 1/10000.

Alternative Names

NR5A2; nuclear receptor subfamily 5, group A, member 2; FTF; nuclear receptor subfamily 5 group A member 2; B1F2; FTZ F1; FTZ F1beta; hB1F; hB1F 2; liver receptor homolog 1; LRH 1; nuclear receptor NR5A2; liver receptor homolog-1; CYP7A promoter-binding f

Entrez Gene ID

UniProt ID

Antigen Description

Binds to the sequence element 5-AACGACCGACCTTGAG-3 of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.

Pathway

Developmental Biology, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Maturity onset diabetes of the young, organism-specific biosystem; Maturity onset diabetes of the young, conserved biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem;