This gene is a member of the G protein-coupled receptor 1 family and encodes a plasma membrane protein. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Mutations in this gene have also been associated with this disease. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Pathway
Class A/1 (Rhodopsin-like receptors); G alpha (s) signalling events; GPCR ligand binding; Peptide ligand-binding receptors.
Citations
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