Rabbit Anti-Human NPHP1 (a.a. 1-48) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

Recombinant human NPHP1 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 1-48 aa of BC062574

Conjugate

Application Notes

IHC: 1:50-1:500

General Notes

This product (Catalog No. DPABH-19117) is a rabbit-derived polyclonal antibody raised against human NPHP1, targeting the amino acid region 1–48 of the protein. This antibody exhibits cross-reactivity with Human NPHP1 from mouse. It has been affinity purified by Protein A. Juvenile nephronophthsis, an autosomal recessive cystic kidney disease, is the primary cause for chronic renal failure in children. The gene for nephronophthsis type 1 (NPHP1) has recently been identified. Nephronophthisis together with Cas it may play a role in the control of epithelial cell polarity. Seems to help to recruit protein tyrosine kinase 2 beta (PTK2B) to cell matrix adhesions, thereby initiating phosphorylation of PTK2B and PTK2B-dependent signaling. NPHP1 expression has been studied in mouse and human systems. Expression in the human adult is widespread but relatively weak. In contrast, expression in adult mouse is strong and localized to the testis. In situ hybridization to whole mouse embryo demonstrates widespread and consistently strong expression throughout all developmental stages. 4 isoforms exist, produced by alternative splicing.
DPABH-19117 is suitable for use in IHC (1:50–1:500) application.
DPABH-19117 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

JBTS4; Nephrocystin 1; nephronophthisis 1 (juvenile); NPHP1; SLSN1

Entrez Gene ID

UniProt ID