Anti-NPEPPS (aa 899-913) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: C-KRDAESIHQYLLQRK, corresponding to C terminal amino acids 899-913 of Human NPEPPS (NP_006301.3)

Conjugate

Application Notes

peptide Detection limit dilution: 1/4000 WB: Use at a concentration of 0.2 - 0.5 μg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 103 kDa).

Alternative Names

NPEPPS; aminopeptidase puromycin sensitive; puromycin-sensitive aminopeptidase; metalloproteinase MP100; MP100; PSA; puromycin sensitive aminopeptidase; cytosol alanyl aminopeptidase; AAP-S;

Entrez Gene ID

UniProt ID

Antigen Description

Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.

Pathway

Adaptive Immune System; Antigen processing: Ubiquitination & Proteasome degradation; Class I MHC mediated antigen processing & presentation; Immune System;