Anti-NOTCH3 monoclonal antibody, clone 598DU7.0.3

Antibody Isotype

IgG1

Clone

598DU7.0.3

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:100-1600

Alternative Names

NOTCH3; Neurogenic locus notch homolog protein 3; Notch 3 extracellular truncation; Notch 3 intracellular domain

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes the third discovered human homologue ofthe Drosophilia melanogaster type I membrane protein notch. InDrosophilia, notch interaction with its cell-bound ligands (delta,serrate) establishes an intercellular signalling pathway that playsa key role in neural development. Homologues of the notch-ligandshave also been identified in human, but precise interactionsbetween these ligands and the human notch homologues remains to bedetermined. Mutations in NOTCH3 have been identified as theunderlying cause of cerebral autosomal dominant arteriopathy withsubcortical infarcts and leukoencephalopathy (CADASIL). [providedby RefSeq].

Pathway

Delta-Notch Signaling Pathway; Dorso-ventral axis formation; Gene Expression; Generic Transcription Pathway; MicroRNAs in cancer; Neural Crest Differentiation; Notch Signaling Pathway; Notch signaling pathway;