General Notes
This product (Catalog No. DPABH-19118) is a rabbit-derived polyclonal antibody raised against human NOS1AP, targeting the amino acid region 285–506 of the protein. This antibody exhibits cross-reactivity with Human NOS1AP from mouse and rat. It has been affinity purified by Protein A. NOS1AP (nitric oxide synthase 1 adaptor protein) encodes an adaptor protein that interacts with neuronal nitric oxide synthase (NOS1) and regulates nitric oxide–mediated signaling pathways. NOS1AP contains a PDZ-binding motif that allows it to associate with NOS1 and modulate its subcellular localization and enzymatic activity. Through this interaction, NOS1AP influences synaptic transmission, neuronal signaling, and cardiovascular electrophysiological processes. Genetic variants of NOS1AP have been associated with altered QT interval duration and susceptibility to cardiac arrhythmias, as well as potential involvement in neuropsychiatric and metabolic disorders. Overall, NOS1AP functions as a regulatory scaffold protein linking nitric oxide signaling to cellular excitability and signal transduction.
DPABH-19118 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:200), Western blot (WB) (1:500–1:4,000) applications.
DPABH-19118 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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