Anti-NOD1 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse, Human

Immunogen

Synthetic peptide within Human CARD4 aa 930-953 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q9Y239

Conjugate

Unconjugated

Application Notes

IHC-P: 1/10 - 1/50; WB: 1/100 - 1/500; ICC/IF: 1/10 - 1/50; Flow Cyt: 1/10 - 1/50;

Alternative Names

NOD1; nucleotide-binding oligomerization domain containing 1; CARD4; NLRC1; CLR7.1; nucleotide-binding oligomerization domain-containing protein 1; NLR family, CARD domain containing 1; caspase recruitment domain family, member 4; caspase recruitment doma

Entrez Gene ID

10392

UniProt ID

A0A024RA73

Antigen Description

Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB.

Pathway

Activated TLR4 signalling; Epithelial cell signaling in Helicobacter pylori infection; Immune System; Interleukin-1 signaling

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More