Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human NME3 aa 50-150. The exact sequence is proprietary.Database link: Q13232
Applications
Application Notes
WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100; Flow Cyt: 1/170; IP: 1/50 - 1/70;
Target
Alternative Names
NME3; non-metastatic cells 3, protein expressed in; nucleoside diphosphate kinase 3; DR nm23; NM23 H3; NDK 3; NDP kinase 3; NDP kinase C; nucleoside diphosphate kinase C; NDPKC; NDPK-C; NM23H3; DR-nm23; NM23-H3; c371H6.2; KIAA0516;
Product Background
Antigen Description
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Pathway
Metabolic pathways, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Pyrimidine metabolism, organism-specific biosystem; Pyrimidine metabolism, conserved biosystem; Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP, organism-specific biosystem;
Citations
Publication ()
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COA
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