Anti-NMDAR3A + 3B monoclonal antibody

Antibody Isotype

IgG1

Species Reactivity

Human

Immunogen

Fusion protein, corresponding to amino acids 780-914 from the intracellular IIIIV loop of Human NR3A + NR3B.

Conjugate

Application Notes

WB: 1 - 10 μg/ml;

Alternative Names

GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A; glutamate [NMDA] receptor subunit 3A; GluN3A; NMDAR3A; N-methyl-D-aspartate receptor subtype 3A; NR3A; NMDAR-L; FLJ45414;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.

Pathway

Alcoholism, organism-specific biosystem; Alcoholism, conserved biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Cocaine addiction, organism-specific biosystem; Cocaine addiction, conserved biosystem; Glutamatergic synapse, organism-specific biosystem;