Anti-NLRP4 (center region) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

NALP4 antibody was raised against a 13 amino acid peptide near the center of human NALP4.

Conjugate

Alternative Names

NLRP4; NLR family, pyrin domain containing 4; CT58; PAN2; RNH2; NALP4; PYPAF4; CLR19.5; NACHT, LRR and PYD domains-containing protein 4; cancer/testis antigen 58; ribonuclease inhibitor 2; PAAD and NACHT-containing protein 2; PYRIN and NACHT-containing pr

Entrez Gene ID

UniProt ID

Antigen Description

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

Pathway

Cytosolic sensors of pathogen-associated DNA; IRF3 mediated activation of type 1 IFN; IRF3-mediated induction of type I IFN; Immune System; Innate Immune System; NOD pathway; Regulation of innate immune responses to cytosolic DNA; STING mediated induction of host immune responses.