Anti-NLRP13 (N-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

NALP13 antibody was raised against a 19 amino acid peptide near the amino terminus of human NALP13.

Conjugate

Alternative Names

NLRP13; NLR family, pyrin domain containing 13; NOD14; PAN13; NALP13; CLR19.7; NACHT, LRR and PYD domains-containing protein 13; NACHT, LRR and PYD containing protein 13; NACHT, leucine rich repeat and PYD containing 13; nucleotide-binding oligomerization

Entrez Gene ID

UniProt ID

Antigen Description

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP13, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]