Anti-NKX2-2 monoclonal antibody, clone OY3/305

Antibody Isotype

IgG2b

Clone

OY3/305

Species Reactivity

Human

Immunogen

Recombinant protein fragment corresponding to human NKX2-2.

Conjugate

Application Notes

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:200) & The optimal working dilution should be determined by the end user.

Alternative Names

NKX2-2; NK2 homeobox 2; NK 2 (Drosophila) homolog B , NK2 transcription factor related, locus 2 (Drosophila) , NKX2B; homeobox protein Nkx-2.2; NKX2.2; NK-2 homolog B; homeobox protein NK-2 homolog B; NK2 transcription factor-like protein B; NK2 transcrip

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.

Pathway

Developmental Biology, organism-specific biosystem; Maturity onset diabetes of the young, organism-specific biosystem; Maturity onset diabetes of the young, conserved biosystem; Regulation of beta-cell development, organism-specific biosystem; Regulation of gene expression in beta cells, organism-specific biosystem; Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, organism-specific biosystem; SIDS Susceptibility Pathways, organism-specific biosystem;