Anti-NIT1 monoclonal antibody (DCABH-735)
Mouse anti-Human NIT1 monoclonal antibody for WB, IHC-P, FC, ICC/IF
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Recombinant full length Human NIT1 produced in HEK293T cells (NP_005591).
WB: 1/1000; IHC-P: 1/50; Flow Cyt: 1/100; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
NIT1; nitrilase 1; nitrilase homolog 1; MGC57670
NIT1 (Nitrilase 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and nitrilase activity. This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene.
Play a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. it is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has apparently no omega-amidase activity such as NIT2 (By similarity). The function about NIT1 antigen include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; nitrilase activity.
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Grsic-Rausch, S; Kobelt, P; et al. Expression and localization of nitrilase during symptom development of the clubroot disease in Arabidopsis. PLANT PHYSIOLOGY 122:369-378(2000).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.