Anti-NIT1 monoclonal antibody (DCABH-735)

Mouse anti-Human NIT1 monoclonal antibody for WB, IHC-P, FC, ICC/IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
5E23
Species Reactivity
Human
Immunogen
Recombinant full length Human NIT1 produced in HEK293T cells (NP_005591).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000; IHC-P: 1/50; Flow Cyt: 1/100; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
NIT1; nitrilase 1; nitrilase homolog 1; MGC57670
Entrez Gene ID
UniProt ID

Product Background


Gene summary
NIT1 (Nitrilase 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and nitrilase activity. This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
Play a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. it is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has apparently no omega-amidase activity such as NIT2 (By similarity). The function about NIT1 antigen include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; nitrilase activity.

Citations


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References


Grsic-Rausch, S; Kobelt, P; et al. Expression and localization of nitrilase during symptom development of the clubroot disease in Arabidopsis. PLANT PHYSIOLOGY 122:369-378(2000).

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