Anti-NFYB (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

NFYB (AAH05317, 1 a.a. ~ 207 a.a) full-length recombinant protein with GST tag. The sequence is MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLP IANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILF AMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLIT TDGQQQNVMVYTTSYQQISGVQQIQFS

Conjugate

Alternative Names

NFYB; nuclear transcription factor Y, beta; HAP3; CBF-A; CBF-B; NF-YB; nuclear transcription factor Y subunit beta; Transcription factor NF-Y, B subunit; CAAT box DNA-binding protein subunit B; nuclear transcription factor Y subunit B; CCAAT-binding trans

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.

Pathway

ATF4 activates genes; ATF6-alpha activates chaperones; Antigen processing and presentation; Direct p53 effectors.