Anti-NFYA (aa 219-318) polyclonal antibody

Species Reactivity

Human

Immunogen

NFYA (AAH39244, 219 a.a. ~ 318 a.a) partial recombinant protein with GST tag. The sequence is AIQRIPLPGAEMLEEEPLYVNAKQYNRILKRRQARAKLEAEGKIPKERRKYLHESRHRHA MARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS

Conjugate

Alternative Names

NFYA; nuclear transcription factor Y, alpha; HAP2; CBF-A; CBF-B; NF-YA; nuclear transcription factor Y subunit alpha; HAP2 CCAAT-binding protein; Transcription factor NF-Y, A subunit; CAAT box DNA-binding protein subunit A; CAAT-box DNA binding protein su

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.

Pathway

ATF4 activates genes; ATF6-alpha activates chaperones; Antigen processing and presentation; Direct p53 effectors